Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| AOST0331 | COG | A Randomized Trial of the European and American Osteosarcoma Study Group to Optimize Treatment Strategies for Resectable Osteosarcoma Based on Histological Response to Pre-Operative Chemotherapy (IND# 12697): A Phase III Intergroup Study | Pediatric CIRB | Completed | |
| AOST06B1 | COG | A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens | Pediatric CIRB | Available to Open | |
| AOST06P1 | COG | Feasibility and Dose Discovery Analysis of Zoledronic Acid with Concurrent Chemotherapy in the Treatment of Newly Diagnosed Metastatic Osteosarcoma: A Groupwide Pilot Study | Pediatric CIRB | Completed | |
| AOST1321 | COG | Phase II Study of Denosumab (IND #127430; NSC# 744010); a RANK Ligand Antibody; for Recurrent or Refractory Osteosarcoma | Pediatric CIRB | Available to Open | |
| AOST1322 | COG | A Phase II Study of Eribulin (IND# 122686; NSC# 707389) in Recurrent or Refractory Osteosarcoma: An Intergroup NCTN Phase II Study | Pediatric CIRB | Completed | |
| AOST1421 | COG | A Phase II Study of Human-Mouse Chimeric Anti-Disialoganglioside Monoclonal Antibody ch14.18 (Dinutuximab; NSC# 764038; IND# 4308) in Combination with Sargramostim (GM-CSF) in Patients with Recurrent Osteosarcoma | Pediatric CIRB | Available to Open | |
| AOST1521 | COG | A Phase 2 Study of GPNMB-targeted Antibody-Drug Conjugate; CDX-011 (Glembatumumab Vedotin; CR011-vcMMAE; IND# 128248; NSC# 763737); in Recurrent or Refractory Osteosarcoma | Pediatric CIRB | Completed | |
| AOST2031 | COG | A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients with Osteosarcoma | Pediatric CIRB | Available to Open | |
| AOST2032 | COG | A Feasibility and Randomized Phase 2/3 Study of the VEFGR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma | Pediatric CIRB | Available to Open | |
| APAL2020SC | COG | Pediatric Acute Leukemia (PedAL) Screening Trial – Developing New Therapies for Relapsed Leukemias | Pediatric CIRB | Available to Open |