Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| NHSR10.2021 | NCI | 21st Century Cures Act and PRA Implementation | Adult CIRB - Late Phase Emphasis | Completed | |
| NRG-BN001 | NRG | Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy Versus Conventional Photon Irradiation With Concomitant and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma | Adult CIRB - Late Phase Emphasis | Available to Open | |
| NRG-BN002 | NRG | Phase I Study Of Ipilimumab; Nivolumab; And The Combination In Patients With Newly Diagnosed Glioblastoma | Adult CIRB - Early Phase Emphasis | Completed | |
| NRG-BN003 | NRG | Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma | Adult CIRB - Late Phase Emphasis | Available to Open | |
| NRG-BN005 | NRG | A Phase II Randomized Trial of Proton vs. Photon Therapy (IMRT) for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas | Adult CIRB - Late Phase Emphasis | Available to Open | |
| NRG-BN007 | NRG | A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab versus Temozolomide in Patients with Newly Diagnosed MGMT (Tumor O-6-Methylganine DNA Methyltransferase) Unmethylated Glioblastoma | Adult CIRB - Late Phase Emphasis | Available to Open | |
| NRG-BN009 | NRG | Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for First or Second Distant Brain Relapse after Upfront SRS with Brain Metastasis Velocity ≥4 Brain Metastases/Year | Adult CIRB - Late Phase Emphasis | Available to Open | |
| NRG-BN010 | NRG | A Safety Run-In and Phase II Study Evaluating the Efficacy, Safety, and Impact on the Tumor Microenvironment of the Combination of Tocilizumab, Atezolizumab, and Fractionated Stereotactic Radiotherapy in Recurrent Glioblastoma | Adult CIRB - Late Phase Emphasis | Available to Open | |
| NRG-BN011 | NRG | A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients with Methylated MGMT Promoter Glioblastoma | Adult CIRB - Late Phase Emphasis | Available to Open | |
| NRG-BN012 | NRG | A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients with Resectable Brain Metastases | Adult CIRB - Late Phase Emphasis | Available to Open |