CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
9938 ETCTN Phase I clinical trial of VX-970 in combination with the topoisomerase I inhibitor irinotecan in patients with advanced solid tumors Adult CIRB - Early Phase Emphasis
9944 ETCTN Phase 2 Study of M6620 (VX-970) in Combination with gemcitabine versus gemcitabine alone in Subjects with Platinum-Resistant Recurrent Ovarian or Primary Peritoneal Fallopian Tube Cancer Adult CIRB - Early Phase Emphasis
9947 ETCTN A Randomized Phase 2 Trial of Cisplatin/Gemcitabine with or without M6620 (VX-970) in Metastatic Urothelial Carcinoma Adult CIRB - Early Phase Emphasis
9948 ETCTN Phase 1 Dose Escalation and Expansion Cohort of Carboplatin and Gemcitabine with or without M6620 (VX-970) in First or Second Recurrence Platinum-Sensitive Epithelial Ovarian, Peritoneal, and Fallopian Tube Cancer Adult CIRB - Early Phase Emphasis
9950 ETCTN A Phase I Study of M6620 (VX-970) in Combination with Cisplatin and XRT in Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC; SDC 10060121) Adult CIRB - Early Phase Emphasis
9952 ETCTN Phase 1 Trial to Determine the Recommended Phase 2 Dose (RP2D) of M6620 (VX‐970) When Combined with Whole Brain Radiotherapy (WBRT) in Patients with Brain Metastases from Lung Cancer Adult CIRB - Early Phase Emphasis
9974 ETCTN A phase II study of olaparib plus cediranib in combination with standard therapy for small cell lung cancer Adult CIRB - Early Phase Emphasis
9979 ETCTN Phase 1 and Pharmacology Study of Oral 5-iodo-2-pyrimidinone-2-deoxyribose (IPdR) as a Prodrug for IUdR-Mediated Tumor Radiosensitization in Brain Metastases Adult CIRB - Early Phase Emphasis
9984 ETCTN A Randomized Phase 2 Study of cediranib in Combination with olaparib versus olaparib alone in men with metastatic castration resistant prostate cancer Adult CIRB - Early Phase Emphasis
A011106 Alliance ALTernate approaches for clinical stage II or III Estrogen Receptor positive breast cancer NeoAdjuvant TrEatment (ALTERNATE) in postmenopausal women: A Phase III Study Adult CIRB - Late Phase Emphasis