CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10449 | ETCTN | A Phase 1 Study of ZEN003694 in Combination with Binimetinib in Solid Tumors with RAS Pathway Alterations and Triple Negative Breast Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10445 | ETCTN | Phase I Dose Escalation and Expansion Study of Tazemetostat in Combination with Topotecan and Pembrolizumab in Recurrent Small Cell Lung Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10440 | ETCTN | A Phase 1/1a Study of Venetoclax, MLN9708 (ixazomib citrate) and Dexamethasone for Relapsed/Refractory Light Chain Amyloidosis | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10437 | ETCTN | A Single Arm Phase II Study of Bone-targeted Sn-117m-DTPA in Symptomatic Castration Resistant Prostate Cancer with Skeletal Metastases | Adult CIRB - Early Phase Emphasis | Completed |
| 10434 | ETCTN | Randomized Phase 2 Study of CPX-351 + Pomalidomide versus CPX-351 in Newly Diagnosed AML with MDS-Related Changes | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10433 | ETCTN | Phase I/Ib trial evaluating the safety and efficacy of BET inhibitor, ZEN003694 with PD-1 inhibitor, nivolumab with or without CTLA-4 inhibitor, ipilimumab in solid tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10422 | ETCTN | A Phase 1/1b Dose Escalation Study of Abemaciclib and Olaparib for Recurrent Platinum-Resistant Ovarian Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10417 | ETCTN | Clinical Evaluation of ASTX727 in Combination with Venetoclax All-Oral Therapy vs. Standard of Care Cytarabine and Anthracycline Induction Chemotherapy for Younger FLT3WT Patients with ELN High-Risk Acute Myeloid Leukemia | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10411 | ETCTN | Phase 2 Study of Rogaratinib (BAY 1163877) in the Treatment of Patients with Sarcoma Harboring Alterations in Fibroblast Growth Factor Receptor (FGFR) 1-4 and SDH-deficient Gastrointestinal Stromal Tumor (GIST) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10410 | ETCTN | A Phase 1 Study of IPdR in Combination with Capecitabine and Radiotherapy in Rectal Cancer | Adult CIRB - Early Phase Emphasis | Completed |