CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10509 | ETCTN | A Phase 1 Study of BET Bromodomain Inhibitor ZEN003694 in Combination with the CDK4/6 Inhibitor Abemaciclib in Patients with NUT Carcinoma and Other Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10508 | ETCTN | A Phase 1 Study of Nivolumab in Combination with ASTX727 in B-cell lymphoma (NHL or HL) with an Expansion Cohort in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10507 | ETCTN | A Phase 1/2 Study of the Bromodomain Inhibitor ZEN003694 in Combination with Etoposide/Platinum in Patients with NUT Carcinoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10505 | ETCTN | A Phase 1/2 Trial of Selinexor and Temozolomide in Recurrent Glioblastoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10504 | ETCTN | A Randomized Phase 2 Study of Atezolizumab with or without Selinexor in Alveolar Soft Part Sarcoma (AXIOM) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10500 | ETCTN | Phase 1/Expansion Study of Tazemetostat Plus Belinostat for the Treatment of Relapsed or Refractory Lymphoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10499 | ETCTN | Phase Ib/II study of ZEN003694 and entinostat in advanced and refractory solid tumors and lymphomas | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10496 | ETCTN | A Phase 2 Study of Ipatasertib in Combination with Pembrolizumab for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10495 | ETCTN | Phase I Trial of DS-8201a (Trastuzumab Deruxtecan) in Combination with Neratinib in Solid Tumors with HER2 Alterations | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10492 | ETCTN | Phase 1/1b Study of AKT Inhibitor Ipatasertib with Chemoradiation for Locally Advanced Head and Neck Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |