CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10217 | ETCTN | A Phase 1b Biomarker-Driven Combination Trial of Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients with Advanced Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10292 | ETCTN | DURVA+ : Evaluation of the Safety and Pharmacodynamics of Anti-PD-L1 Antibody MEDI4736 (durvalumab) in Combination with Chemotherapy in Patients with Advanced Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| EAQ171CD | ECOG-ACRIN | Implementing a Virtual Tobacco Treatment in Community Oncology Practices: “Smoke Free Support Study 2.0” | Cancer Prevention and Control CIRB | Available to Open |
| 10553 | ETCTN | A Phase 2 Study of Darolutamide in Combination with Leuprolide Acetate in Hormone-Therapy Naïve Recurrent and/or Metastatic Androgen Receptor (AR) Positive Salivary Gland Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-BR009 | NRG | A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET) | Adult CIRB - Late Phase Emphasis | Available to Open |
| A092001 | Alliance | Phase 2 Randomized Trial of Neoadjuvant or Palliative Chemotherapy with or Without Immunotherapy for Peritoneal Mesothelioma | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1712 | SWOG | A Randomized Phase II Study of Ruxolitinib (NSC-752295) in Combination with BCR-ABL Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia (CML) Patients with Molecular Evidence of Disease | Adult CIRB - Late Phase Emphasis | Available to Open |
| EA5161 | ECOG-ACRIN | Randomized Phase II Clinical Trial of Cisplatin/Carboplatin and Etoposide (CE) alone or in Combination with Nivolumab as Frontline Therapy for Extensive Stage Small Cell Lung Cancer (ED-SCLC) | Adult CIRB - Late Phase Emphasis | Available to Open |
| ARST1921 | COG | A Safety, Pharmacokinetic and Efficacy Study of a γ-Secretase Inhibitor, Nirogacestat (PF 03084014; IND# 146375), in Children and Adolescents with Progressive, Surgically Unresectable Desmoid Tumors | Pediatric CIRB | Available to Open |
| A151216 | Alliance | Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST) | Adult CIRB - Late Phase Emphasis | Available to Open |