CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10410 | ETCTN | A Phase 1 Study of IPdR in Combination with Capecitabine and Radiotherapy in Rectal Cancer | Adult CIRB - Early Phase Emphasis | Completed |
| S0518 | SWOG | Phase III Prospective Randomized Comparison of Depot Octreotide plus Interferon Alpha versus Depot Octreotide plus Bevacizumab (NSC #704865) in Advanced; Poor Prognosis Carcinoid Patients | Adult CIRB - Late Phase Emphasis | Completed |
| ARET0332 | COG | A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy: A Groupwide Phase III Study | Pediatric CIRB | Completed |
| EAA172 | ECOG-ACRIN | Phase 1/2 Study of Daratumumab, Bortezomib, Dexamethasone with or without Venetoclax in Relapsed/Refractory Multiple Myeloma with Assessment for t(11;14) Status | Adult CIRB - Late Phase Emphasis | Completed |
| E1105 | ECOG | A Randomized Phase III Double-Blind Placebo-Controlled Trial of First-line Chemotherapy and Trastuzumab with or without Bevacizumab for Patients with HER-2/NEU Over-expressing Metastatic Breast Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| 9742 | ETCTN | Multicenter Phase II Study of Nivolumab in Previously Treated Patients with Recurrent and Metastatic Nasopharyngeal Carcinoma | Adult CIRB - Early Phase Emphasis | Completed |
| NSABP-C-11 | NSABP | A Phase III Study Evaluating the Role of Perioperative Chemotherapy in Patients with Potentially Resectable Hepatic Colorectal Metastases | Adult CIRB - Late Phase Emphasis | Completed |
| 9899 | ETCTN | A Phase 1 Trial of the Combination of the Heat Shock Protein-90 (HSP90) inhibitor Onalespib (AT13387) and the Cyclin-Dependent Kinase (CDK) inhibitor AT7519M in patients with Advanced Solid Tumors | Adult CIRB - Early Phase Emphasis | Completed |
| ADVL1315 | COG | A Phase 1 Study of the VEGF Receptor Tyrosine Kinase Inhibitor Axitinib (INLYTA; 123101) in Children with Recurrent or Refractory Solid Tumors | Pediatric CIRB | Completed |
| NRG-HN003 | NRG | A Phase I and Expansion Cohort Study of Adjuvant Cisplatin; Intensity-Modulated Radiotherapy; and MK-3475 (Pembrolizumab) in High-Risk Head and Neck Squamous Cell Carcinoma (HNSCC) | Adult CIRB - Early Phase Emphasis | Completed |