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    • Create and Update the Signatory Institution Worksheet
      • Completing The Annual Signatory Institution Worksheet
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      • Establishing a Principal Investigator
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      • Changing the PI on a Study
    • Submit a Study Closure
    • Report A Potential Unanticipated Problem Or A Serious Or Continuing Noncompliance
    • Request an Assent Waiver
      • Completing The Assent Waiver Worksheet
    • Notify the CIRB about the participation of an incarcerated participant
      • Completing The Notification of Incarcerated Participant Worksheet
      • Institution Q & A
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      • Completing The Translation Application
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      • Completing The Waiver Of Consent Application
      • Determining Waiver Of Consent Requirements
      • End User Licensing Agreement (Eula) Consent Form Language Q & A
      • Review of Translated Consent Forms, PROs, and Other Patient-Facing Documents
      • Submitting Recruitment/participant Materials For Review
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For Institutions
  • IRBManager Basics
  • Overview of the Study Review Process
  • Becoming A Signatory Institution
  • Navigating The CIRB For NCI Division of Cancer Prevention (DCP) Consortia Sites And Cancer Prevention Clinical Trial Network (CP-CTNET) Organizations
  • Create and Update the Signatory Institution Worksheet
  • Creating and Updating the Annual Principal Investigator Worksheet
  • How to Open a Study
  • Change the PI on a Study
  • Submit a Study Closure
  • Report A Potential Unanticipated Problem Or A Serious Or Continuing Noncompliance
  • Request an Assent Waiver
  • Notify the CIRB about the participation of an incarcerated participant

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How to Use IRBManager

The following is a list of how-to quickguides designed to assist you in completing you using IRBManager for your local context considerations.

  • Starting a New Worksheet
  • Copying Worksheets
  • Deleting a Worksheet
  • Finding Completed Worksheets
  • What are Stages and What Do They Mean?
  • I Am a PI, How Do I Find the Worksheets That Require My Signature?
  • Finding Approval Letters and Approved Boilerplate Language
  • Frequently Asked Questions About IRBManager
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The NCI Central Institutional Review Board

401 N. Washington Street, Ste. 700
Rockville, MD 20850

The Central Institutional Review Board for the National Cancer of Institute is fully accredited by the Association for the Accreditation of Human Research Protection Program, Inc.