CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| A011202 | Alliance | A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy | Adult CIRB - Late Phase Emphasis | Available to Open |
| A022004 | Alliance | Randomized Trial of Consolidation Targeted Adjuvant Therapy with Encorafenib and Cetuximab versus Usual Care for Patients with Stage II/III BRAF V600E Colon Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| A082101 | Alliance | Multimodality Therapy with Immunotherapy in Stage I-IIIA Sarcomatoid Mesothelioma | Adult CIRB - Late Phase Emphasis | Available to Open |
| A221701 | Alliance | Phase III Placebo-Controlled Trial to Evaluate Dexamethasone Use for Everolimus-Induced Oral Stomatitis: Prevention Versus Early Treatment Approaches: MIST (My Individualized Stomatitis Treatment) | Cancer Prevention and Control CIRB | Completed |
| A031704 | Alliance | PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab vs. VEGF TKI Cabozantinib with Nivolumab: A Phase III Trial in Metastatic Untreated Renal Cell Cancer [PDIGREE] | Adult CIRB - Late Phase Emphasis | Available to Open |
| A071401 | Alliance | Phase II Trial of SMO/AKT/NF2/CDK Inhibitors in Progressive Meningiomas with SMO/AKT/NF2/CDK Pathway Mutations | Adult CIRB - Early Phase Emphasis | Available to Open |
| A091802 | Alliance | Phase II Randomized Trial of Avelumab Plus Cetuximab versus Avelumab Alone in Advanced Cutaneous Squamous Cell Carcinoma of the Skin (cSCC) | Adult CIRB - Late Phase Emphasis | Available to Open |
| A221504 | Alliance | A Randomized, Double-Blind, Placebo-Controlled Pilot Study of an Oral, Selective Peripheral Opioid Receptor Antagonist in Advanced Non-Small Cell Lung Cancer | Cancer Prevention and Control CIRB | Available to Open |
| A092105 | Alliance | Randomized Phase 2 Study of Nivolumab and Ipilimumab with or without Cabozantinib in Patients with Advanced Nasopharyngeal Carcinoma that have Progressed after Platinum Treatment and Immunotherapy | Adult CIRB - Late Phase Emphasis | Available to Open |
| A031201 | Alliance | Phase III Trial of Enzalutamide (NSC # 766085) Versus Enzalutamide; Abiraterone and Prednisone for Castration Resistant Metastatic Prostate Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |